脑胶质瘤术后放疗联合同步超选动脉化疗的近期疗效观察

The short-term therapeutic effect observation of postoperative concurrent radiotherapy and chemotherapy for intracranial glioma

目的：评价脑胶质瘤术后放疗联合同步超选动脉化疗治疗脑胶质瘤的疗效。方法：对29例脑胶质细胞瘤患者行肿瘤全切或大部切除术后予以三维适形放疗,总剂量DT 60 Gy/4-6周,并同步于术后10-15 d（平均12 d）开始行超选介入动脉灌注尼莫司汀（Nimustine hydrochoride,ACNU）化疗,每4周1次,每次2.5 mg/kg,共进行4-6次化疗结束。与25例术后放疗＋静脉化疗患者结果进行比较。结果：放疗联合同步超选动脉化疗组总有效率（肿瘤消失＋肿瘤明显缩小）为75.8%,与术后放疗联合同步静脉化疗组相比有显著差别（P〈0.05）。结论：脑胶质瘤术后行放疗联合同步超选动脉化疗是一种切实有效的治疗脑胶质瘤的手段和方法。

Objective：To evaluate the efficacy of postoperative concurrent radiotherapy and chemotherapy for intracranial glioma.Methods：29 patients of glioma who underwent total or subtotal resection received three dimensional conformal radiation therapy（3D-CRT）,with total dose of 60 Gy/4-6 weeks and superselective interventional intra-arterial chemotherapy with（Nimustine hydrochoride）ACNU given 2.5 mg/kg each time;the chemotherapy was repeated every four weeks,and four or six cycles was one complete course.Other 25 patients received 3D-CRT and concurrent chemotherapy via vein.Results：General efficiency was 75.8%（complete remission ＋ partial response）in intra-arterial chemotherapy group,which was significant higher than in the vein chemotherapy group（P0.05）.Conclusion：Postoperative concurrent radiotherapy and superselective interventional intra-arterial chemotherapy is an effective therapy for gliomas.