北京地区儿童幽门螺杆菌感染情况调查

Survey of Helicobacter pylori Infection Among Children with Alimentary Tract Discomforts in Beijing Area

目的调查北京地区消化道不适儿童幽门螺杆菌感染情况,为做好防治工作提供依据。方法采用间接固相免疫层析技术对2007年3月-2009年3月来北京儿童医院门诊就诊的13 795名消化道不适患儿进行幽门螺杆菌（Helicobacter pylori,Hp）感染检测,并对年龄、性别和季节因素与儿童幽门螺杆菌感染率进行相关分析。结果北京地区消化道不适儿童Hp感染率为13.40%~35.48%,平均感染率为20.34%。7 607名男性患儿现症感染阳性率18.79%,IgG阳性率21.31%;6 188例女性患儿现症感染阳性率16.53%,IgG阳性率19.15%;男性感染率明显高于女性。随着年龄的增长,Hp感染呈上升趋势。从7岁开始Hp感染显著增高,到17岁时达到35.48%。一、四季度儿童Hp感染率明显高于二、三季度。结论北京地区消化道不适儿童Hp感染率低于国内报道平均水平,但高于发达国家水平。儿童Hp感染呈现年龄、性别和季节性差异。

Objective To investigate Helicobacter pylori（Hp） infection in children with alimentary tract discomforts in Beijing area,and to provide the evidence for better prevention and treatment of the disease.Methods The status of Hp infection in 13,795 children with alimentary tract discomforts hospitalized in Outpatient Department of Beijing Children＇s Hospital from March 2007 to March 2009 was detected by indirect solid phase immune chromatographic assay.The correlation between the detection rate of Hp and the influence of age,sex and season was analyzed.Results The infection rate of Hp in the surveyed children was 13.40%~35.48%,with the average infection rate of 20.34%.The current infection rate of 7,607 boys was 18.79%,and the positive rate of IgG was 21.31%.The current infection rate of 6,188 girls was 16.53%,and the positive rate of IgG was 19.15%.The current infection rate of boys was significantly higher than that of girls.The infection rate of Hp showed an ascending tendency with the age increasing.There was a significant increase of Hp infection rate from 7 years old,and the infection rate was 35.48% at the age of 17 years.The Hp infection rate was higher in Autumn and Winter than in Summer and Spring.Conclusions Hp infection rate in children with alimentary tract discomforts of Beijing area was lower than the average level reported in China,but it was higher than that in developed country.There were age,sex and seasonal differences in children with Hp infection.