新生儿先天性梅毒55例临床分析

Clinical Analysis of 55 Cases Congenital Syphilis

目的通过对先天性梅毒患儿临床分析,探讨新生儿先天性梅毒的有效诊断及防治方法。方法对住院诊断为先天性梅毒的55例新生儿临床资料进行回顾性分析。结果早期先天性梅毒临床特征及表现依次为:皮肤损害、肝功能损害、长骨骨骼损坏,梅毒组异常率明显高于对照组(P<0.05);55例先天性梅毒患儿早产率、引产率、宫内发育迟缓率、营养不良率明显高于对照组(P<0.05);早期应用青霉素治疗先天性梅毒具有良好疗效。结论对早产儿出现各种不明原因皮疹、肝功能损害、长骨骨骼损坏、肝脾肿大,应高度怀疑先天性梅毒,单纯TPPA结果阳性不能确诊为先天性梅毒。

Objective To explored prevention and cure methods and diagnose of congenital syphilis in neonate by clinical analysis.Methods The data of 55 hospitalized cases with congenital syphilis was used by retrospective study.Results The earlier period clinical feature and appearance with congenital syphilis were skin lesion,hepatic function lesion,long bone ossature deterioration in which syphilis group abnormality rate were higher than control group（P0.05）.The rate of immature labor,artificial labor,intrauterine growth retardation,cacotrophia with syphilis group were higher than control group（P0.05）.It was good therapeutic effect for penicillinum to cure with congenital syphilis in the earlier period.Conclusions There were on clean reasons of erythra,hepatic function lesion,long bone ossature deterioration,splenohepatomegalia with premature infant who were suspected highly with congenital syphilis.It can not diagnose congenital syphilis with simple positive result of TPPA.