胃癌手术患者预后影响因素分析

Analysis of Influential Factor of Prognosis for Patients with Gastric Cancer Undergoing Operation

目的探讨胃癌患者术后生存的影响因素。方法应用单因素和多因素Cox回归分析方法,回顾性分析2000年1月-2005年12月有完整临床资料和随访资料的289例胃癌患者临床资料。结果 289例胃癌患者术后1年、3年和5年生存率分别为80.96%、50.87%和42.91%;单因素分析表明:肿瘤浸润深度、淋巴结转移、远处转移、Bor-rmann分型、肿瘤部位、组织病理学分级、TNM分期和肿瘤的根治度、化疗疗程对胃癌患者的5年生存率均有影响(P<0.05)。Cox回归分析显示:Borrmann分型、病理组织学分级、肿瘤浸润深度、淋巴结及远处转移,TNM分期和化疗6个疗程7个因素是影响胃癌术后生存的独立因素(P<0.05)。结论胃癌的Borrmann分型、病理组织学分级、肿瘤浸润深度、淋巴结转移、远处转移、TNM分期和化疗6个疗程是影响其术后生存的重要因素。

Objective To analyze the related factors affecting the prognosis of gastric cancer patients undergoing operation.Methods The clinical characteristics and follow up data of 289 patients with gastric cancer treated from January 2000 to December 2005 in central hospital were retrospectively analyzed by univariate and multivariate analytical methods.Results In the 289 cases,the overall 1-year,3-year and 5-year survival rate was 80.96%,50.87% and 42.91% respectively.In the univariate analysis,depth of invasion,lymph node metastasis,Borrmann type,tumor location,TNM stage,pathological type,operative method and chemotherapy for 6 cycles were related to the prognosis of patients with gastric cancer.Multivariate Cox regression analysis showed that TNM stage,Borrmann type,pathological type,depth of invasion,lymph node metastasis,and chemotherapy for 6 cycles were the related factors for patients with gastric cancer.Conclusions TNM stage,Borrmann type,pathological type,depth of invasion,lymph node metastasis and chemotherapy for 6 cycles are important prognostic factors for patients with gastric cancer undergoing operation.