肝硬化患者血清谷丙转氨酶、谷草转氨酶和总胆红素与肝纤维化标志物的相关性研究

Correlation of ALT,AST,TBIL and Liver Fibrosis Indexes in Patients with Liver Cirrhosis

目的探讨谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）与肝纤维化标志物（PCⅢ、Ⅳ-C、LN、HA）的相关性。方法分别测定100例肝硬化患者和30例健康体检者血清ALT、AST、TBIL水平和肝纤维化标志物（PCⅢ、Ⅳ-C、LN、HA）水平。结果与对照组比较,肝硬化组血清ALT、AST、TBIL水平显著上升（P〈0.05）;在肝硬化不同级组之间,血清ALT、AST、TBIL水平随着肝功能Child-Pugh分级的增高而逐渐上升,其水平为C级组〉B级组〉A级组,各级组间比较差异有统计学意义（P〈0.05）;与对照组比较,肝硬化组血清肝纤维化标志物（PCⅢ、Ⅳ-C、LN、HA）水平显著上升（P〈0.05）;ALT、AST、TBIL与肝纤维化指标之间呈显著正相关（r=0.520~0.797,P=0.000~0.017）。结论联合检测血清ALT、AST、TBIL及PCⅢ、Ⅳ-C、LN、HA水平对肝硬化的早期诊断、评估病情以及预后有着重要临床意义。

Objective To investigate the correlation of ALT,AST,TBIL and liver fibrosis indexes（PCⅢ,Ⅳ-C,LN and HA） in patients with liver cirrhosis.Methods The serum ALT,AST,TBIL and the liver fibrosis indexes（PCⅢ,Ⅳ-C,LN and HA） of 100 cases of patients with liver cirrhosis and 30 cases of healthy individuals were measured,Results The serum ALT,AST and TBIL levels of the cirrhosis group was significantly higher than that of the control group（P0.05）;The serum ALT,AST and TBIL levels in the cirrhosis group increased significantly with Child-Pugh score raised,the C-grade group B-grade group A-grade group,compared the difference was significant（P0.05）;The serum liver fibrosis indexes（PCⅢ,Ⅳ-C,LN and HA） of the cirrhosis group was significantly higher than that of the control group（P0.05）;The ALT,AST,TBIL and PCⅢ,Ⅳ-C,LN,HA levels were significant positive correlation（r=0.520~0.797,P=0.000~0.017）.Conclusion Combined measuring the ALT,AST,TBIL and liver fibrosis indexes has important clinical significance for the early diagnosis of liver cirrhosis,evaluation and prognosis of the disease.