摘要
目的探讨联合检测抗环瓜氨酸肽抗体(抗CCP抗体)及类风湿因子(RF)对类风湿关节炎(RA)的临床诊断价值。方法分别用胶体金免疫层析法(GICA)、速率散射比浊法联合检测52例RA患者、37例非RA的自身免疫性疾病患者和15例正常人血清中抗CCP抗体和RF。结果抗CCP抗体和RF联合检测的特异性、阳性预测值、阳性似然比、阴性似然比与任何单一项检测比较差异均有统计学意义(P<0.05)。结论联合检测抗CCP抗体和RF可明显提高类风湿关节炎的诊断率。
Objective To evaluate the clinical diagnosic value of anti-cyclic citrullinated peptide（anti-CCP） antibody and rheumatoid factor（RF） in patients with rheumatoid arthritis（RA）.Methods Anti-CCP antibody was determined by quantitative GICA and rheumatoid factor by BNP nephelometer in 52 cases of RA,37 cases of non-RA rheumatic diseases and 15 healths.Results The diagnosis specificity,positive predictive value,positive /negative likelihood ratios of combinate determination of anti-CCP antibodyand RF were significantly higher than either one.Conclusion The combinate determination of anti-CCP antibody and rheumatoid factor will remarkably improve the accuracy for diagnosis of RA.
出处
《实用预防医学》
CAS
2011年第8期1554-1555,共2页
Practical Preventive Medicine
关键词
抗环瓜氨酸肽抗体
类风湿因子
类风湿关节炎
Anti-cyclic citrullinated peptide antibody
Rheumatoid factor
Rheumatoid arthritis
