GHRPs对CHF大鼠存活时间影响及心脏活性研究

Study on the Effect of GHRPs on Survival Time and Cardioprotective Function in Rats with CHF

目的研究GHRPs对ADR诱导的CHF大鼠存活时间影响，探索CHRPs的CHF直接治疗作用及其心脏保护性作用机制，为CHF生物学治疗提供新方法、新途径。方法采用ADR经ip制作CHF大鼠模型，尾静脉注射法分别给GHRPs和复方丹参和生理盐水，观察4组CHF大鼠存活时间。结果ADR大鼠CHF模型基本符合临床心肌病性CHF的病理生理过程；GH—RPs和复方丹参都能延长CHF大鼠存活时间，总计GHRPs比复方丹参组多存活15～17天。结论复方丹参和GHRPs均能改善重症CHF大鼠恶液质状态，延长其存活时间，GHRPs的心脏保护作用比复方丹参更强。

Objective To observe the effect of GHRPs on the survival time in CHF model of rats in a purpose to explore the cardioprotective effect mechanisms of GHRPs on heart,so as to provide new method,new pathway for CHF biological therapy. Methods The establishment of rat CHF model was caused by ADR and the survival time in the four group rats with serious CHF after the different therapy through injection of GHRP- 2, GHRP -6, eoumpound recipe Danshen or NaCl into tail vein was observed. Results The rat model of ADR - induced CHF basically hit the target of Bishop indexes of CHF which suggested that the CHF model of rats reduced by ADR was successfully similar with the pathological processes of cardiomyopathy style CHF. Both GHRPs and the coumpound recipe Danshen could prolong the survival time in rats with serious CHF reduced by ADR and the GHRPs groups were 15 to 17 days longer than the lateral one. Conclusion Both GHRPs and the coumpound recipe Danshen could ameliorate the dyscrasia condition and prolong the survival time in rats with serious CHF,and the cardiaoprotective activity of GHRPs was much stronger compared with the coumpound recipe Danshen.