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风湿痛消丸的临床疗效观察 被引量:1

Clinical curative of Feng Shi Tong Xiao Pill
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摘要 目的 观察风湿痛消丸对类风湿关节炎患者血清中自细胞介素(IL)-1、肿瘤坏死因子(TNF)-α、IL-4和IL-10的影响.方法 将60例类风湿关节炎患者完全随机分为2组,雷公藤多甙组30例,给予雷公藤多甙片进行治疗;风湿痛消丸组30例,给予风湿痛消丸进行治疗;对照组30例为我院正常体检健康者,应用酶联免疫吸附法(ELISA)检测各组患者IL-1、TNF-α、IL-4和IL-10的水平.结果 给药前雷公藤多甙组与风湿痛消丸组患者血清中IL-1和TNF-α水平与对照组比较都有明显升高[IL-1:(72.3±9.4)ng/L、(70.5±10.4)ng/L比(9.9±2.4)ng/L;TNF-α:(109.4±14.5)ng/L、(110.3±13.2)ng/L比(12.6±1.7)ng/L;P<0.05],IL-4和IL-10的水平与对照组比较有明显下降[IL-4:(30.2±6.8)ng/L、(27.4±7.4)ng/L比(125.3±13.2)ng/L;IL-10:(9.6±2.2)ng/L、(9.8±1.4)ng/L比(60.3±7.4)ng/L;P<0.05];给药后雷公藤多甙组和风湿痛消丸组患者各项指标与对照组相比,差异无统计学意义(P>0.05).结论 风湿痛消丸对类风湿关节炎有明显的治疗作用. Objective To observe the levels of IL-1, TNF-α, IL-4 and IL-10 in serum of patients with rheumatoid arthritis(RA). Methods Totally 60 cases were randomly divided into Feng Shi Tong Xiao Pill group and Glucosida Tripterygii TOTA group given Glucoside Tripterygium Total auspended matter. Thirty normal people who were done health check-ups in control group. Levels of IL-1, TNF-α, IL-4 and IL-10 in patients with RA were measured by enzyme-linked immunoabsorbent assay. Results Before medicine administration, the levels of IL-1,IL-4, IL-10and TNF-α were significantly different between patients with RA and blank group (P 〈 0.05). After medicine administration, the levels of IL-1, IL-4, IL-10and TNF-α were not significantly different between patients with RA and blank group(P 〉 0.05). Conclusion Feng Shi Tong Xiao Pill can improve RA.
作者 张雯丽 李慧
出处 《中国医药》 2011年第9期1137-1138,共2页 China Medicine
关键词 风湿痛消丸 临床疗效 细胞因子 关节炎 类风湿 Feng Shi Tong Xiao Pill Clinical curative Cytokine Arthritis, rheumatoid
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  • 1黄清春,黄伟毅,沈鹰,张声鹏,徐秋英,陈光星,马伟.复方丹参注射液对CIA大鼠滑膜细胞凋亡及关节功能的影响[J].中国组织工程研究与临床康复,2001,10(20):58-59. 被引量:6
  • 2杨德华,钱玉中,张国恩.痰瘀同治在中晚期类风湿性关节炎的进展[J].疑难病杂志,2005,4(1):56-57. 被引量:16
  • 3郭智萍,赵建,李石玲.类风湿性关节炎的MRI表现与早期诊断[J].中国医学影像学杂志,2006,14(5):377-379. 被引量:6
  • 4Nanjundaiah S M, Venkatesha S H, Yu H, et al. Celas- trus and its bioactive celastrol protect against bone dam- age in autoimmune arthritis by modulating osteoimmune cross-talk[ J ]. J Biol Chem, 2012,287 (26) : 22216- 22226.
  • 5吴启富,贺向无,刘毅,等.类风湿性关节炎血瘀证的分析研究[J].中国中西医结合风湿病杂志,1996,5(1):19.
  • 6Ho J H, Hong C Y. Salvianolic acids: small compounds with multiple mechanisms for cardiovascular rotection [J].J Biomed Sci, 2011,18:30.
  • 7Cheng C Y, Su C C. Tanshenone II A inhibits Hep-J5 cells by increasing calreticulin, caspase 12 and GADD153 protein expression [ J]. Int J Mol Med, 2010, 26(3) :379-385.
  • 8Gao S, Liu Z, Li H, et al. Caudiovascular actions and thereutic potential of tanshinone ⅡA [ J ]. Atherosclero- sis, 2012,220( 1 ) :3-10.
  • 9Xu S, Little P J, Lan T, et al. Tanshinone ⅡA attenu- ates and stabilizes atherosclerotic plaques in apolipopro- tein-E knockout mice fed a igh cholesterol diet [J]. Arch Biochem Biophys, 2011,515 (1-2) :72-79.
  • 10李燕,周京国,张勇.青蒿琥酯联合甲氨蝶呤对类风湿关节炎滑膜细胞增殖和凋亡的影响[J].中国药业,2010,19(13):16-18. 被引量:10

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