尿毒症合并尿路细菌感染及药敏试验结果分析

Pathogens and drug resistance analysis of uremia with urinary tract infection

目的了解尿毒症合并尿路细菌感染的病原菌的现状及体外耐药性,为临床提供诊断和治疗依据。方法回顾分析尿毒症住院患者582例,其中39例合并尿路感染的临床资料。结果尿毒症患者中段尿细菌培养阳性率为6.7%,以肠杆菌科19株(48.7%)和肠球菌属16株(41.0%)为主;肠杆菌科对β-内酰胺类抗菌药物耐药率较高(68%～100%),对哌拉西林/他佐巴坦、亚安培南耐药率低(5%);肠球菌属对万古霉素均敏感,对其他抗菌药物的耐药率较高(63%～100%)。结论尿毒症患者尿路细菌感染率高,且耐药严重;尿毒症患者注意预防尿路感染,合理使用抗菌药物。

Objective To investigate the pathogens and drug resistance in urinary tract infection patients with uremia and to provide suggestion for diagnosis and treatment.Methods A retrospective analysis of 582 in patients with uremia were collected.Of the 582 patients 39 had urinary tract infection.Results The incidence of urinary tract infection patients with uremia was 6.7%.The isolation rate of Enterobacteriaceae was the highest,which accounted for 48.7%（19/39）,followed by Enterococcus 41%（16/39）.The resistance rate of Enterobacteriaceae to β-lactam antibiotics was 68%-100% and the resistance rate of it to piperacillin/tazobactam,imipenem was 5%.Enterococcus to vancomycin were susceptibility and the resistance of it to the other antibiotics was 63%-100%.Conclusion The urinary tract infection rate of uremic patients was high and the drug resistance rates of pathogens were serious.More attention should be paid to prevent the urinary tract infection of uremic patients and antibiotics should be used rationally and regularly.