水貂出血性肺炎流行病学调查及绿脓杆菌疫苗研究进展

Epidemiological Investigation of Mink Hemorrhagic Pneumonia and Research Progress of Pseudomonas aeruginosa Vaccine

由绿脓杆菌引起的水貂出血性肺炎近几年在我国各地养殖场频繁发病。总结了该病发病情况和流行特点,概述了水貂出血性肺炎疫苗的研究进展。调查发现,我国水貂出血性肺炎的死亡率为6%～54%,以沿海气候潮湿的地区发病较多,全国流行的血清型以G、B、C型为主,与国外流行的主要血清型相同。目前用于防治水貂出血性肺炎的疫苗产品以灭活疫苗为主,外膜蛋白(OMP)、脂多糖(LPS)和鞭毛等组分疫苗和基因工程疫苗在人医上尝试较多,兽医领域应用较少,但OMP疫苗和基因工程疫苗有提供共同保护性抗原的优点,在预防水貂出血性肺炎上有较好的应用前景。

Mink hemorrhagic pneumonia which was caused by Pseudomonas aeruginosa（PA）outbreak frequently in recent years.Prevalence characteristics of this disease and the research progress of the PA vaccine were summarized.The survey showed that the motrality rates of mink hemorrhagic pneumonia in China were 6%~54%,and the disease mostly outbreak in the humid area along the coast.Serotype G,B and C were the dominant serotypes among the isolates,which were in accordance with previous observations from other countries.The main vaccine product was inactivated vaccine,vaccine antigens such as lipopolsaccharide（LPS）,outer membrane protein（OMP）,flagella and genetic engineering vaccine were researched in human medical treatment,the vaccine composed of OMP and genetic engineering had the advantage of preventing mink hemorrhagic pneumonia caused by the multiserotype of PA.