负载脯氨酸及其衍生物催化的不对称C—C键形成反应研究进展

Research Progress in Supported Proline and Proline Derivatives as Recyclable Organocatalysts for Asymmetric C—C Bond Formation Reactions

近年来脯氨酸及其衍生物催化的不对称有机反应受到了广泛关注,将其负载于载体上使用也引起了人们的极大兴趣.负载方式大致分为3种:共价键负载,离子对结合或物理吸附等作用负载,以及在离子液体中的两相催化剂.本文对近年来出现的负载脯氨酸及其衍生物催化的不对称反应(Aldol反应、Michael加成反应)研究进展进行了综述.

In recent years, L-proline and L-proline derivatives were successfully used as organocatalysts in asymmetric reactions. There are three different general approaches for organocatalyst immobilization： covalently supported catalysts, non-covalently supported catalysts, and biphasic catalysts in ionic liquids. This review summarizes some immobilized organocatalysts, highlighting their application, recoverability, and reusability in Aldol and Michael addition reactions.