复合刺激对亚健康大鼠模型耐疲劳能力及血清SOD、MDA的影响

Effect of Compound Stimulus on the Fatigue Resistance of Sub-healthy Rat Models and SOD and MDA in Serum

目的:观察复合刺激对亚健康大鼠模型耐疲劳能力及其血清SOD、MDA的影响。方法:采用游泳运动、睡眠剥夺和夹尾刺激等复合因素制造亚健康大鼠模型,检测动物体重、进食量、耐疲劳能力及血清SOD、MDA等指标的变化。结果:模型组动物体重低于正常组,饮水量、进食量均明显少于正常组,5 min内不动时间明显多于正常组,血清SOD活性明显低于正常组,MDA明显高于正常组。结论:复合因素造模法兼顾了亚健康的成因和表现,模型动物的宏观表现和微观指标均具备亚健康的基本特征,该造模方式具有一定的科学性和合理性。

Objective： To observe the effect of compound stimulus on the fatigue resistance of sub-healthy model rats and SOD and MDA in serum.Methods： The complex stimulus factors such as swimming,sleep deprivation and tail clamp were used to make sub-healthy rat models to detect the changes of the animal weight,food intake,fatigue resistance and SOD,MDA in serum.Results： The weight of the animal group was lower than that of the normal group;the water and food intake was less than that of the normal group;the immobility time in 5 min was longer than that of the normal group;the activity of SOD in serum was significantly lower than that of the normal group;MDA was significantly higher than that of the normal group.Conclusion： The complex stimulus modeling method gives consideration to the formation and the performance of the sub-health,and the macro performance and the micro indicators of the model animals possess the basic characteristics of the sub-health.The modeling approach has certain scientific rationality.