弥可保治疗外伤性视神经挫伤的临床疗效观察

Clinical observation of methylcobalamin in the treatment of optic nerve contusion

目的对照观察和评价弥可保和腺苷钴胺片治疗外伤性视神经挫伤的临床疗效,评估弥可保的治疗有效性和优越性。方法将37例外伤性视神经挫伤患者随机分为二组,分别用弥可保和腺苷钴胺片治疗,比较两组间视力改善及视神经萎缩发生情况。结果弥可保治疗组视力改善有效率为63.15%,腺苷钴胺片对照组视力改善有效率为27.78%;两组差别具有统计学意义(P<0.05);弥可保治疗组视神经萎缩发生率为46.15%,腺苷钴胺片对照组视神经萎缩发生率为72.22%,两组差别具有统计学意义(P<0.05)。结论弥可保对外伤性视神经挫伤的治疗有明显的临床疗效,是一种疗效肯定的治疗外伤性视神经挫伤的药物,其对视功能的恢复优于腺苷钴胺片。

Objetive To compare the effect of methylcobalamin for the treatment of optic nerve with cobamamide tablets Methods 37 patients with contusion of optic nerve were randomized into two groups and the each group was treated with methylcobalamin or cobamamide tablets respectively Visual acuity and the incidence Of optic atrophy were compared between the methylcobalamin and cobamamide tablets groups.Results Improvement of visual acuity was achieved 63.15%in the group treated with methylcobalamin and 27.78%in the controlled group with cobamamide tablets;the incidence of optic atrophy in the two group 46.15%and 72.22%,respectively（P0.05）.Conclusions Treatment with Methycobal is effective,safe and conformative for contusion of optic nerve,and is more effective than cobamamide tablets.