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微调三号方(WD-3)对小鼠大肠癌肝转移灶nm23-H1 mRNA、CD44 mRNA、VEGF mRNA的影响 被引量：5

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摘要 目的:探讨WD-3对小鼠大肠癌肝转移灶nm23-H1 mRNA、CD44 mRNA、VEGF mRNA的影响。方法:建立BALB/c鼠结肠腺癌肝转移模型,随机分为6组:模型组,西药组,中药低、中、高剂量组,中西药组,分组治疗4周。半定量RT-PCR检测nm23-H1 mRNA、CD44 mRNA、VEGF mRNA表达水平。结果:与模型组比,中西药组较其他各组转移灶nm23-H1 mRNA升高,与模型组比较有统计学意义(P<0.05)。中西药组可降低转移灶CD44 mRNA、VEGF mRNA的表达,与模型组比较有统计学意义(P<0.05),中高剂量组亦可降低转移灶VEGF mRNA表达水平,与模型组比较有统计学意义(P<0.05),但与中西药组比较无统计学意义(P>0.05)。结论:WD-3可降低肝转移灶CD44 mRNA、VEGF mRNA的表达,升高nm23-H1 mRNA,提示对小鼠大肠癌肝转移可能具有抑制作用。
作者 王旺胜 尤建良 浦琼华
机构地区 无锡市中医院
出处 《四川中医》 2011年第8期21-23,共3页 Journal of Sichuan of Traditional Chinese Medicine
基金 无锡市科技局 卫生局指令性课题[项目编号(ZZD0809)]
关键词 大肠癌 肝转移 小鼠nm23-H1 CD44 VEGF
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献12

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二级参考文献13

  • 1Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published..The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer[J].World Journal of Gastroenterology,2001,7(3):431-434. 被引量：25
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共引文献35

同被引文献113

引证文献5

二级引证文献34

四川中医
2011年 第8期

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