PRL腺瘤的侵袭性相关因素分析

The analysis of factors relative to the invasiveness in patients with Prolatinomas

目的:评估垂体PRL腺瘤的侵袭性与术前血清PRL、肿瘤大小、性别、年龄的关系,为PRL腺瘤患者制定进一步治疗方案提供依据。材料和方法:收集并综合分析昆医附一院首次住院治疗且资料完整的33例泌乳素(PRL)腺瘤患者的临床资料,分别检测术前血清PRL水平,分析患者的年龄组成、性别差异,测量磁共振(MR I)影像上肿瘤大小,按照W ilson改良Hardy分类方法判断肿瘤侵袭性。结果:本组资料中33例PRL腺瘤患者,侵袭性腺瘤12例,非侵袭性腺瘤21例;男性8例,女性25例。Logistic回归分析:较大腺瘤发生侵袭的可能性是较小腺瘤的1.435倍;女性PRL腺瘤患者肿瘤发生侵袭的可能性是男性的12.5%。侵袭性与非侵袭性PRL腺瘤的大小、性别比较差异均有统计学意义(P=0.000,P=0.015)。结论:肿瘤的侵袭性与肿瘤大小、性别相关,与术前PRL水平、年龄无关。

Objective： To assess the relationships between preoperative PRL levels, tumor size, gender, age and tumor invasiveness of Prolactinomas and provide evidences on further therapeutic strategies for patients with Prolactinomas. Materials and Meth- ods： We collected and analyzed 33 initial treated cases of patients with prolactin （PRL） adenomas of our department with complete data. All patients were tested preoperative PILL, analyzed age composition, gender differences and the tumor size of MRI. The invasiveness of pituitary adenomas were judged according to Hardy＇s classification scheme modified by Wilson. Result： There were 33 patients with PRL - secreting pituitary adenomas, 8 males and 25 females, 12 patients with invasive adenomas and 21 patients with noninvasive adenomas. Logistic regression analysis indicated that the incidence of invasive adenomas in patients with a larger tumor is 1. 435 times higher than that of patients with a smaller tumor. The occurrence rate of invasive adenomas in women is 12. 5% of men. The size and gender of invasive adenomas and the size of non - invasive adenomas was statistically significant （ P = 0. 000, P = 0. 015 ）. Conclusion： The invasion of tumor was closely related to the size and gender, not to the preoperative PRL levels and age.