儿童癫痫的围产期高危因素分析

Perinatal Risk Factors for Epilepsy in Children

目的:研究儿童癫痫相关的围产期高危因素。方法:随访16986例新生儿后期癫痫的患病情况,分为儿童癫痫组与非癫痫组,比较两组各项围产期高危因素,进行单因素与多因素统计分析。结果:随访期内儿童癫痫的发病例数为118例(6.95‰),癫痫的发病率在1岁以下的儿童最高(27.12%)。儿童癫痫的发生与孕周、高龄产妇、低出生体重、流产史、宫内窘迫、喂养方式、孕期感染、子痫、胎盘早剥、新生儿惊厥都有相关性,并且孕周、子痫和新生儿惊厥是儿童癫痫发生的独立危险因素。结论:儿童癫痫的发生与围产期高危因素密切相关,这对临床儿童癫痫的诊疗可能有提示作用。

Objective： To study of epilepsy in children associated with perinatal risk factors. Methods： We follow up 16,986 cases of post-neonatal prevalence of epilepsy. Comparing childhood epilepsy and non-epilepsy group, the perinatal risk factors analyzed by univariate and multivariate statistical analysis. Results： During follow-up period, the number of cases of epilepsy in children is 118 patients （6.95 %0） and the incidence of epilepsy in children under 1 year is the highest （27.12%）. Gestational age, maternal age, low birth weight, miscarriage, history of fetal distress, feeding patterns, infections during pregnancy, eclampsia, placental abruption, neonatal seizures are related with childhood epilepsy. Gestational age, Eclampsia and neonatal seizures were independent risk factors. Conclusions： The incidence of epilepsy in children with perinatal risk factors closely, which is help for the clinical diagnosis and treatment of epilepsy in children.