摘要
目的：了解肾脏转运体介导抗病毒药物肾排泄的研究现状，为临床合理用药提供参考。方法：对近年抗病毒药物与肾脏转运体相关的文献进行综述。结果：有机阴离子转运体（Organic Anion Transporters OAT1-3）和有机阳离子转运体（Organic Cation Transporters, OCT1-3）介导药物流入细胞内．而ATP结合转运体（ATP Binding Cassette P-gp, MRP2-5）介导药物从细胞排出。寡肽转运体（Peptide Transporters, PEPT1-2）介导伐昔洛韦双向扩散。结论：通过介导药物的摄取和排出，肾脏转运体在调节体内常用抗病毒药物浓度时发挥重要的作用。
Objective： To understand the situation of the transporters involved in the transport of antiviral drugs in kidney, and provide advices for further study. Method： Review related literatures about the research status of transporters mediated antiviral drugs in kidney. Results： Organic anion transporters （OAT1 - 3） and organic cation transporters （OCT1-3） mediate the intracellular flux, and adenosine 5＇ -triphosphate （ATP） binding cassette transporters （P-gp,MRP2-5） mediate the cellular efflux of antiviral drugs. The peptide transporters （PEPT1-2） mediate bi-directional facilitated diffusion of valacyclovir. Conclusions： Transporters play an important role in the regulation of antiviral drugs concentration in body by mediating the antiviral drugs flux and efflux in kidney.
出处
《药品评价》
CAS
2011年第12期28-31,共4页
Drug Evaluation
