摘要
目的分析2型糖尿病视网膜病变(DR)的特点,探讨2型糖尿病患者血清胱抑素C(Cys-C)和高敏C反应蛋白(hs-CRP)的水平与DR的相关性。方法选择325例2型糖尿病患者进行眼底检查或眼底荧光造影,根据2002年国际分级标准将其分为5期,即无明显视网膜病变(1期),轻度非增殖性糖尿病视网膜病变(2期),中度非增殖性糖尿病视网膜病变(3期),重度非增殖性糖尿病视网膜病变(4期),增殖性糖尿病视网膜病变(5期)。记录病程,检测糖化血红蛋白(HbA1c)、hs-CRP、Cys-C、24h尿白蛋白定量(24h-UAE),分析DR各组的特点及相关因素。结果在纳入的病例中,DR的总患病率为47%;与1期相比,2、3、4、5各期的病程,HbA1c,hs-CRP,Cys-C,24h-UAE均显著升高(P<0.05),且依次性升高(P均<0.05);多元回归分析显示,Cys-C、hs-CRP分别是DR患病率及其严重程度的独立危险因素,分别与2型糖尿病患者的患病病程、HbA1c、24h-UAE呈正相关。结论 DR及其病情严重程度与Cys-C、hs-CRP密切相关,Cys-C、hs-CRP有可能成为预测DR发生发展的生物学指标。
Objective To analyze the features of type 2 diabetic retinopathy(DR),and to explore the relationship between serum cystatin C(Cys-C),high sensitivity C-reactive protein(hs-CRP) and retinopathy in patients with type 2 diabetes.Method 325 cases of type 2 diabetes patients were recruited to have a fundus examination and fundus fluorescence angiography.Based on the findings,5 groups were establised according to 2002 international classification standard,no obvious retinopathy(group 1),mild non-proliferating diabetic retinopathy(group 2),moderately non-proliferating diabetic retinopathy(group 3),severe non-proliferating diabetic retinopathy(group 4),and proliferating diabetic retinopathy(group 5).Clinical courses were monitored,while glycated hemoglobin(HbA1c),hs-CRP,Cys-C,24-hour urinary albumin quantitative(24h-UAE) were determined.Results In all cases,total DR prevalence accounted for about 47 percent.Compared with the group 1,clinical courses,HbA1c,hs-CRP,Cys-C,24h-UAE in the other four groups were significantly increased(P〈0.05),in the order from group 2 to 5(P〈0.05).Multiple regression analysis showed that Cys-C and hs-CRP were independent risk factors for DR prevalence rate and the severity of DR,and were positively correlated with the duration of type 2 diabetes,the sicken HbA1c and 24h-UAE,respectively.Conclusions DR and severity are closely related with Cys-C and hs-CRP.Cys-C and hs-CRP may serve as biological indicators to predict the occurrence and development of DR
出处
《山东大学学报(医学版)》
CAS
北大核心
2011年第8期1-4,共4页
Journal of Shandong University:Health Sciences
关键词
2型糖尿病
胱抑素C
高敏C反应蛋白
视网膜病变
High sensitivity C-reactive protein; Cystatin C; Retinopathy; Type 2 diabetes mellitus; High sensitivity C-reactive protein; Cystatin C; Retinopathy; Type 2 diabetes mellitus; High sensitivity C-reactive protein; Cystatin C; Retinopathy; Type 2 diabetes mellitus;