白蛋白联合甘露醇在大面积脑梗死中的临床观察

Clinical Observation of Albumin and Mannitol on Large Cerebral Infarction

目的:观察白蛋白联合甘露醇治疗大面积脑梗死的疗效。方法:将大面积脑梗死68例随机分为对照组(n=33)和治疗组(n=35,对照组应用甘露醇治疗,治疗组白蛋白联合小剂量甘露醇治疗,比较两组临床疗效。结果:治疗组的总有效率71.4%显著高于对照组的51.5%(P<0.05),治疗组肾功能不全、低钠血症、低蛋白血症、应激性溃疡等并发症的发生率均明显低于对照组(P<0.05)。结论:白蛋白联合小剂量甘露醇治疗大面积脑梗死的疗效优于甘露醇。

Objective： To observe the effect of albumin and mannitol on large cerebral infarction. Methods： 68 patients with large cerebral infarction were randomly divided into control group and treatment group. The control group was treated by mannitol, and the treatment group was treated by albumin and mannitol. The clinical effects were compared between the two groups. Results： The total effective rate （71.4%） in the treatment group was significantly higher than that （51.5%） in the control group （P〈0.05）. The incidence of rental failure,hyponatremia, hypoproteinemia and stress ulcer were lower in the treatment group than those in the control group, （all P〈0.05）. Conclusions： The effects of albumin and mannitol were superior to mannitol on large cerebral infarction.