精神分裂症与G72基因多态性的关联

Association between G72 gene polymorphism and schizophrenia

目的:探讨在云南省汉族人群中D-氨基酸氧化酶激活基因(G72)多态性与精神分裂症的关联性。方法:采用聚合酶链式反应-限制性片段长度多态(PCR-RFLP)方法,在云南汉族276例精神分裂症患者和312例健康对照者中进行G72基因3个多态位点(rs9558562,rs45476401,rs3918341)的分型。结果:各位点在病例组和对照组中基因型分布均符合Hardy-Weinberg平衡。无论在男女混合样本,还是分别在男性、女性样本中,rs9558562,rs45476401,rs3918341在病例组和对照组间的等位基因频率分布差异均无显著性(P均>0.05)。结论:G72基因rs9558562,rs45476401和rs3918341多态与云南汉族精神分裂症发病无显著相关。

Objective：The aim of this study was to assess the association between single nucleotide polymorphisms（SNPs） of G72 gene and schizophrenia in Yunnan Han population.Method：Three SNPs（rs9558562,rs45476401 and rs3918341） of G72 gene were genotyped in 276 schizophrenia patients and 312 healthy subjects using polymerase chain reaction-restriction fragment length polymerase（PCR-RFLP）.Results：Genotype frequencies for three SNPs were all in Hardy-Weinberg equilibrium both schizophrenia cases and controls.The allele frequencies for three SNPs were not significantly different between schizophrenia patients and controls（P 0.05）.The same results existed in the male and female groups respectively（P 0.05）.Conclusion：The present results indicated that rs9558562,rs45476401 and rs3918341 in the G72 gene were not associated with schizophrenia in Yunnan Han population.