抑郁症和冠心病共病患者的临床特征

Clinical characteristics of depressive patients with coronary heart disease

目的:探讨伴发冠心病的抑郁症患者的临床特征。方法:对50例伴有冠心病的抑郁症患者(共病组)和50例单纯抑郁症患者(抑郁组),使用汉密尔顿抑郁量表24项(HAMD)、汉密尔顿焦虑量表(HAMA)和社会功能缺陷筛选量表(SDSS)评定临床表现和社会功能,使用舍曲林治疗12周后再次评定。结果:入组及治疗12周末,共病组HAMD、HAMA及SDSS总分均显著高于抑郁组(P均<0.05),治疗12周共病组减分率显著低于抑郁组(P<0.05)。结论:与不伴发冠心病患者相比,伴发冠心病的抑郁症患者抑郁及焦虑症状重,社会功能缺陷明显,治疗效果较差。

Objective：To explore clinical characteristics of depressive patients with coronary heart disease.Method：Hamilton depression rating scale（HAMD）,Hamilton anxiety rating scale（HAMA） and social disability screening schedule（SDSS） were administered to 50 depressed patients with and 50 depressed patients without coronary heart disease before and after 12 week sertraline treatment.Results：Patients with coronary heart disease had higher scores in HAMD,HAMA and SDSS at baseline and week 12（P0.05）,and lower reductive rates.Conclusion：The patients with depressive disorder and coronary heart disease has more severe symptoms,more social function impairment,and less curative effect.