非酒精性脂肪肝与生长激素相关性研究

Relationship between nonalcoholic fatty liver disease and growth hormone

目的探讨非酒精性脂肪肝(NAFLD)与生长激素(GH)的关系。方法入选NAFLD组38例,非NAFLD组42例,测定GH、腰围(WC)、空腹血糖(FPG)、空腹胰岛素(FIns)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP),谷氨酸氨基转移酶(ALT)、γ-谷氨酰转肽酶(GGT)水平,计算体质量指数(BMI)、胰岛素抵抗指数(HOMA-IR)。结果 NAFLD组GH、HDL-C水平显著低于非NAFLD组(P<0·05);NAFLD组BMI、WC、FPG、FIns、HOMA-IR、TG、hsCRP、ALT、GGT水平显著高于非NAFLD组(P<0·05)。GH、HDL-C与NAFLD呈负相关,WC、BMI、FPG、FIns、HOMA-IR、TG、hsCRP、ALT、GGT与NAFLD呈正相关。结论 GH与NAFLD密切相关,低水平GH可能是NAFLD危险因素,与肥胖、胰岛素抵抗、血脂紊乱等共同参与了NAFLD的发生与发展。

Objective To explore the relationship between non-alcoholic fatty liver disease （NAFLD） and growth hormone （GH）. Methods Thirty-eight patients with NAFLD, 42 patients without NAFLD were enrolled in this study. The levels of waist circumference （WC）, serum growth hormone （GH）, fasting plasma glucose （FPG）, fasting insulin （ Fins）, total cholesterol（ TC）, triglyeeride （ TG）, high density lipoprotein cholesterol （ HDL-C ）, low-density lipoprotein cholesterol（LDL-C） , high sensitivity C reactive protein（hsCRP） , alanine aminotransferase （ALT） , gamma glutamyltransferase（GGT） were measured. Body mass index （BMI） and insulin resistance index （HOMA-IR） were calculated. Resuits In NAFLD group, the levels of GH and HDL-C were significantly lower than those in non-NAFLD group （ P 〈 0. 05） ;In NAFLD group, the levels of WC, BMI, FPG, Fins, HOMA-IR, TG, hsCRP, ALT, GGT were significantly higher than those in non-NAFLD group. The levels of GH and HDL-C were negatively correlated with NAFLD. The levels of WC, BMI, FPG, Fins, HOMA-IR, TG, hsCRP, ALT, GGT were positively correlated with NAFLD. Conclusions GH is closely related with NAFLD. Low-level GH may be a risk factor for NAFLD and may participate in the occurrence and development of NAFLD.