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TCF7L2基因多态性与2型糖尿病发病关系的研究进展 被引量：5

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摘要 2型糖尿病（T2DM）是由环境和遗传因素共同作用而发生的多基因遗传病，具有明硅的遗传倾向和显著的遗传异质性：近年来T2DM的发病率急速上升，预计到2030年全世界范嗣内的成年患者将达到3．6亿多。
作者 杨可名 游娜
机构地区 南京医科大学第一临床医学院 南京医科大学第二附属医院内分泌科
出处 《实用老年医学》 CAS 2011年第4期341-343,共3页 Practical Geriatrics
关键词 2型糖尿病 基因多态性 发病关系 多基因遗传病 遗传异质性 遗传因素 T2DM 遗传倾向
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献21

  • 1Tong Y, Lin Y, Zhang Y, et al. Association between TCF7L2 gene polymorphism and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology ( HuGE ) review and meta-analysis [ J ]. BMC Med Genet, 2009,10:15.
  • 2Cauchi S, Meyre D, Dina C, et al. Transcription factor TCFTL2 genetic study in the French population-expression in human beta-cells and adipose tissue and strong association with type 2 diabetes [ J ]. Diabetes, 2006,55 (10) :2903-2908.
  • 3Grant SF, Thorleifsson G,Reynisdottir I, et al, Variant of transcription factor 7-like .2 ( TCF7L2) gene confers risk of type 2 diabetes [ J ]. Nat Genet, 2006,38(3) :320-323.
  • 4Slattery ML, Folsom AR, Wolff R, et al. Transcription factor 7-like 2 polymorphism and colon cancer [ J ]. Cancer Epidemiol Biomarkers Prey, 2008, 17(4) :978-982.
  • 5Yi F, Brubaker PL, Jin T. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta [ J ]. J Biol Chem, 2005, 280 (2) : 1457-1464.
  • 6Lyssenko V, Lupi R, Marchetti P, et al. Mechanisms by which common variants in the TCFTL2 gene increase risk of type 2 diabetes [ J ]. J Clin Invest, 2007, 117(8) :2155-2163.
  • 7Palmer ND, Hester JM, An SS, et al. Resequencing and analysis of variation in the TCFTL2 gene in Afri- can Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant [ J ].Diabetes, 2011, 60(2) :662-668.
  • 8娄青林,卞茸文,解雨春,顾刘宝,夏晖,欧阳晓俊,莫永珍.TCF7L2基因单核甘酸多态性与汉族2型糖尿病遗传易感性关系的研究[J].中国糖尿病杂志,2009,17(12):895-898. 被引量：6
  • 9Chang YC, Chang TJ, Jiang YD, et al. Association study of the genetic polymorphisms of the transcription factor 7-like 2 TCF7L2 )gene and type 2 diabetes in the Chinese population [ J ].Diabetes, 2007, 56 ( 10 ) : 2631-2637.
  • 10Ng MC, Tam CH, Lam VK, et al. Replication and identification of novel variants at TCFTI2 associated with type 2 diabetes in Hong Kong Chinese [ J ]. J Clin Endocrinol Metab, 2007, 92(9) : 3733-3737.

二级参考文献12

  • 1Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCFTL2) gene confers risk of type 2 dia betes. Nat Genet, 2006, 38:320-323.
  • 2Groves CJ, Zeggini E, Minton J, et al. Association analysis of 6736 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes, 2006, 55:2640-2644.
  • 3Zhang C, Qi L, Hunter DJ, et al. Variant of transcription factor 7- like E (TCFTL2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes, 2006, 55:2645 2668.
  • 4Scott LJ, Bonnycastle C, Wilier CJ, et al. Association of transcription factor 7-like 2 (TCFTL2) variants with type 2 diabetes in a Finnish sample. Diabetes, 2006, 55:2649-2653.
  • 5Cauchi S, Meyre D, Dina C, et al. Transcription factor TCFTL2 genetic study in the French population: expression in human β- cells and adipose tissue and strong association with type 2 diabetes. Diabetes, 2006, 55:2903- 2908.
  • 6Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature, 2007, 445:881-885.
  • 7Yi F, Brubaker PL, Jin T, et al. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-eatenin and glycogen synthase kinase-3beta. J Biol Chem, 2005, 280: 1457-1464.
  • 8Zeggini E, McCarthy MI. TCF7L2 : the biggest story in diabetes genetics since HLA. Diabetologia, 2007, 50 : 1-4.
  • 9Miyake K, Horikawa Y, Hara K, et al. Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet,2008,53 : 174-180.
  • 10Ren Q, Han XY, Wang F, et al. Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. Diabetologia, 2008,51 : 1146-1152.

共引文献5

同被引文献60

  • 1熊瑜,高绪胜,祝淮阳.应用噬菌体法对老年糖尿病合并肺结核初治的耐药性分析[J].实用老年医学,2013,27(5):412-414. 被引量：4
  • 2李秀钧,邬云红.糖尿病是一种炎症性疾病?[J].中华内分泌代谢杂志,2003,19(4):251-253. 被引量：253
  • 3胡忠义,倪莲娣,靳安佳,董惠贤,钟敏,李建农,翁心华.噬菌体生物扩增法快速检测结核分枝杆菌方法学研究[J].中华结核和呼吸杂志,2004,27(12):801-805. 被引量：62
  • 4王洁,崔振玲,胡忠义,张滢蓉,乐军,张文宏,翁心华.噬菌体法同时检测四种一线抗结核药物耐药性[J].中华传染病杂志,2006,24(2):102-105. 被引量：31
  • 5陆再英,钟南山.内科学[M].7版.北京:人民卫生出版社,2008:775.
  • 6李安德,曲亚伟,张培元.血糖水平对糖尿病结核的临床影响研究[J].中国防痨杂志,2007,24(增刊):72.
  • 7Hasui Y, Marutsuka K, Asada Y, et al. Relationship between serum prostate specific antigen and histological pros- tatitis in patients with benign prostatic hyperplasia[ J]. Pros- tate, 1994, 25(2) :91-96.
  • 8Schatteman PH, Hoekx L, Wyndaele JJ, et al. Inflammation in prostate biopsies of men without prostatic malignancy or clinical prostatitis: correlation with total serum PSA and PSA density [J]. Eur Urol, 2000, 37(4) :402-412.
  • 9Al.Daghri NM,Al.Attas OS,Alokail MS,et al. Adiponectingene variants and the risk of coronary artery disease in pa.tients with type 2 diabetes[J].Mol Biol Rep,2011,38(6):3703.3708.
  • 10Bingham NC,Anderson KK,Reuter AL,et al.Selective lossof leptin receptors in the ventromedial hypothalamic nucleusresults in increased adiposity and a metabolic syndrome[J].Endocrinology,2008,149(5):2138.2148.

引证文献5

二级引证文献12

实用老年医学
2011年 第4期

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