APN MMP-9hs-CRP在冠心病老年患者中的表达及临床意义

Expression of APN,MMP-9 and hs-CRP in Elderly Patients with Coronary Artery Disease and its Clinical Significance

目的:探讨脂联素(APN)、血清基质金属蛋白酶(MMP-9)、超敏C反应蛋白(hs-CRP)与老年冠心病及其严重程度的关系。方法:选择老年冠心病患者85例,分为稳定型心绞痛(SA)组,急性冠脉综合征(ACS)组,正常对照组。测量一般临床资料,分别对APN,MMP-9,hsCRP进行测定。结果:各组间外周血ANP,MMP-9,hs-CRP差异显著有统计学意义(P<0.01)。单支病变、多支病变组ANP,MMP-9(P<0.01)。结论:血浆APN、MMP-9、hs-CRP水平与老年冠心病血管病变的严重程度和斑块稳定性显著相关。

Objective：To study the relationship between the level of adiponectin（APN）,serum matrix metalloproteinase（MMP-9） and high sensitive C-reactive protein（hs-CRP） and senile coronary heart disease.Method：85 patients with senile coronary heart disease were divided into stable angina（SA） group,acute coronary syndrome（ACS） group and normal control group.General clinical data were measured and the expression of APN,MMP-9 and hs-CRP were determined.Result：The expression of ANP,MMP-9 and hsCRP were significantly different among three groups in peripheral blood（P0.01）.The expression of ANP and MMP-9 were significantly different in single-vessel disease and multi-vessel disease group（P0.01）.Conclusion：The plasma level of APN,MMP-9 and hs-CRP was significantly related to severity of vascular disease and plaque stability in elder patients with coronary heart disease.