志贺菌261株菌型分布及耐药分析

Serotype Distribution and Drug Resistance of 261 Shigella Strains

目的了解上海市闵行区志贺菌菌型分布及药物敏感特点,为痢疾防治提供科学依据。方法将2007—2009年送检的肠道腹泻病人中分离出的志贺菌进行菌型分型,采用K-B法进行药物敏感试验。结果 2007—2009年间共检出261株志贺菌,主要为福氏志贺菌和宋氏志贺菌。其中福氏志贺菌190株(72.80%),宋氏志贺菌71株(27.20%)。190株福氏志贺菌中有10个血清型(F1 a14株,F2 a100株,F2b13株,F4 a4株,F4 c38株,FX变种7株,FY变种11株,F4b、F5 a、F6型各1株)。261株志贺菌对复方新诺明、氨苄西林、四环素、利福平、萘啶酸的耐药率分别为87.36%、88.12%、86.97%、81.23%、96.93%。结论该区志贺菌的耐药情况严重,且多重耐药,所以应加强耐药性监测和防治。

[Objective]To understand the serotype distribution and drug resistance of Shigella in Minhang District of Shanghai City,and provide scientific evidence for diarrhea prevention and control.[Methods]The serotype of shigella isolated from fecal samples of intestinal diarrhea patients were grouped in Minhang District during 2007-2009.Antibiotic susceptibility was conducted by K-B method.[Results]A total of 261 strains were isolated,shigella flexneri accounted for 72.80%,followed by shigella sonnei which accounted for 27.20%.Ten serotypes（F1a14 strains,F2a100 strains,F2b13strains,F4a4strains,F4c38 strains,FX mutation 7strains,FY mutation11strains,F4b 1strain,F5a1strain,F6 1strain） were distributed in 190 strains of shigella flexneri.The rate of resistance to cotrimoxazole,ampicillin trihydrate,tetracycline,rifampcin,nalidixic acid was 87.36%,88.12%、86.97%,81.23%,96.93% respectively.[Conclusion]Shigella showes seriously multi-drug resistance in Minhang District and should be pay more attention to surveillance and control of drug resistance.