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右美托咪定对老年患者术后舒芬太尼自控静脉镇痛效果的影响 被引量:36

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摘要 目的探讨右美托咪定对老年病人术后舒芬太尼自控静脉镇痛效果的影响。方法择期拟行腹腔手术的病人40例,年龄>60岁,ASA分级Ⅱ~Ⅲ级,随机分为两组(n=20):舒芬太尼(R组)和舒芬太尼+右美托咪啶组(RD组),于手术结束即刻行病人自控静脉镇痛,R组舒芬太尼100μg,RP组采用舒芬太尼100μg+右美托咪定200μg,均用生理盐水稀释至150 ml,负荷剂量6 ml,背景输注速率2 ml/h,单次给药剂量3 ml,锁定时间15 min,维持VAS评分≤4分,Ramsay评分2~3分。记录术后24 h内舒芬太尼用量、PCIA总按压次数;记录术后镇痛期间恶心、呕吐、心动过缓、低血压、镇静过度和呼吸抑制等不良反应的发生情况,术后24 h时行Ramsay镇静评分。结果与R组比较,RD组术后24 h内舒芬太尼用量降低、PCIA总按压次数减少、Ramsay镇静评分升高,术后恶心和呕吐的发生率降低(P<0.05)。两组均未发生过度镇静和呼吸抑制。结论右美托咪定不仅可减少老年病人术后舒芬太尼PCIA的用量,且不良反应少。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第16期3043-3044,共2页 Chinese Journal of Gerontology
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参考文献10

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