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缺血后处理对大鼠骨骼肌缺血再灌注肾损伤ICAM-1表达的影响及其意义 被引量：1

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摘要 目的通过观察骨骼肌缺血再灌注肾损伤中细胞间黏附分子-1(ICAM-1)表达的变化,探讨缺血后处理对骨骼肌缺血再灌注肾损伤的影响及其意义。方法将24只雄性Wister大鼠随机分为4组,Ⅰ组仅进行常规麻醉,不阻断后肢血流;Ⅱ组为缺血4 h无再灌注组;Ⅲ组为缺血4 h后再灌注6 h组;Ⅳ组为缺血3 h 57 min于再灌注前给予1 min灌注1 min缺血,重复3次后继续再灌注5 h 57 min。分别检测血清中尿素氮(BUN)含量、肾组织中超氧化物歧化酶(SOD)含量及肾组织中ICAM-1蛋白表达情况。结果 I组ICAM-1表达不明显;Ⅱ、Ⅲ组ICAM-1表达呈上升趋势;Ⅳ组表达下调;其余三组与I组比较有显著性差异(p 0.05),Ⅳ组与Ⅲ组比较,有显著性差异(P<0.05)。BUN和SOD含量:Ⅱ、Ⅲ组逐渐升高,Ⅲ组较Ⅱ组升高明显(P<0.05);Ⅳ组二者含量均相应下降,与III组比较有显著性差异(P<0.05)。结论骨骼肌缺血再灌注后肾组织中ICAM-1的表达明显上调,缺血后处理可明显抑制ICAM-1的表达,降低BUN、SOD含量,对骨骼肌缺血再灌注肾损伤有明显的保护作用。
作者 张彦荣 高翔 蔡建辉
机构地区 河北医科大学第二医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第16期3121-3122,共2页 Chinese Journal of Gerontology
关键词 缺血再灌注损伤 骨骼肌 肾损伤 细胞间黏附分子-1 缺血后处理
分类号 R74 [医药卫生—神经病学与精神病学]
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中国老年学杂志
2011年 第16期

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