驱白巴布期对缺铜、缺锌大鼠血清中微量元素及免疫球蛋白水平的影响

Effects of Qubaibabuqi on Trace Elements and Immunoglobulin in Serum of Copper and Zinc Deficient Rat

目的研究驱白巴布期对缺铜、缺锌大鼠模型血清中微量元素及免疫球蛋白水平的影响。方法采用饲料法建立微量元素Cu、Zn缺失模型,初步探讨复方驱白巴布期中的微量元素在体内吸收情况,分别采用免疫浊度法进行相关免疫球蛋白水平的测定。结果成功地建立微量元素Cu、Zn缺失动物模型,给药后,复方驱白巴布期中微量元素Cu、Zn在模型动物体内均有不同程度的吸收,且对其他微量元素也有一定的影响:降低大鼠体内Cu、Zn元素水平,能够升高血清中Fe、Mn、Se元素水平,降低Mg、Sr元素水平,但对Ca元素无影响;升高血清中的Cu、Zn元素水平,能够降低血清中Fe、Se元素水平,升高血清中Ca、Mg、Sr元素水平,但对Mn元素水平无影响;Cu、Zn元素缺失与补充,对大鼠血清中免疫球蛋白IgG、IgA、IgM均有不同程度地调节作用。结论复方驱白巴布期中的微量元素Cu、Zn能够被机体吸收,且影响其他微量元素及常量元素的吸收,同时对机体IgG、IgA、IgM有一定影响,为该药进行作用物质研究提供依据。

OBJECTIVE To study the effects of Qubaibabuqi on trace elements and immunoglobulin in serum of copper and zinc deficient rats. METHODS Preliminary studying on internal resorption of trace elements by establishing model of copper or zinc deficient rat in controling feeds, determinating the level of related immune globulin by nephelometry. RESULTS The animal model of Cu, Zn-lack was constructed successfully. After administration on the animal. model, the Cu, Zn in the compound Qubaibabuqi had a different degree absorption, and it also had a certain effect on other trace element. Lower the level of Cu, Zn in rats could rise the levels of Fe, Mn, Se and decrease the levels of Mg, Sr in the serum, but it had no effect on Ca. Opposite to this, rising the levels of Cu, Zn could low the the level of Fe, Se and rise the level of Ca, Mg, Sr, but it had no effect on Mn. At the same time, the loss and supplement of Cu, Zn have different degree regulate on IgG, IgA, IgM in the serum of SD rats. CONCLUSION Cu, Zn in the compound recipe Qubaibabuqi can be absorbed by organism, and effect the absorption of other trace elements and macroelements. Meanwhile it has some influence on IgG, IgA, IgM of organism and supply evidence to its basic study.