异氟醚和依托咪酯对重症肌无力患者胸腺切除术Bcl-2的影响

Effect of Isoflurane and Etomidate on Serum Levels of Bcl-2 in Patients with Myasthenia Gravis Thymectomy

目的探讨异氟醚和依托咪酯对重症肌无力患者胸腺切除术血清Bcl-2的影响。方法 40例重症肌无力胸腺切除术患者,随机分为异氟醚组和依托咪酯组,每组20例。采用ELISA法检测患者术前、术后血清Bcl-2水平的变化。结果异氟醚组血清Bcl-2术后低于术前(P<0.01),依托咪酯组血清Bcl-2水平术后高于术前(P<0.01)。两组血清Bcl-2水平术前比较差异无统计学意义(P>0.05),术后血清Bcl-2水平依托咪酯组高于异氟醚组(P<0.01)。结论异氟醚用于重症肌无力患者麻醉可降低Bcl-2水平,而依托咪酯则升高Bcl-2水平,异氟醚可能比依托咪酯更适合用于重症肌无力患者胸腺切除术的麻醉。

OBJECTIVE To investigate the effect of isoflurane and etomidate on serum levels of Bcl-2 in patients with rnyasthenia gravis thymectomy. METHODS Forty patients with rnyasthenia gravis thymectomy were randomly divided into isoflurane group and etornidate group. The levels of Bcl-2 were measured at preoperative and postoperative with ELISA method. RESULTS The serum Bcl-2 levels postoperative were lower than preoperative in isoflurane group （P〈0.01）. The serum Bcl-2 levels postoperative were higher than preoperative in etornidate group （P〈0.01）. There was no significant difference of Bcl-2 serum levels between the two groups before surgery （P〉0.05）. The Bcl-2 serum levels in etornidate group were higher than isoflurane group postoperative （P〈0.01）. CONCLUSION Isoflurane can reduce the serum levels of Bcl-2 during thyrnectorny, while etornidate increases the level ofBcl-2. Isoflurane is more suitable than etomidate for patients with thyrnectomy.