低氧诱导因子1α在白蛋白过负荷致肾小管上皮细胞转分化中的作用
被引量：1
摘要
长期蛋白尿可致肾脏纤维化，细胞外基质（ECM）的主要来源之一是转分化的肾小管上皮细胞（TEC），因此上皮细胞-间充质细胞转分化（EMT）是蛋白尿患者肾脏纤维化的主要机制之一。低氧诱导因子1（HIF-1）可诱导多种细胞转分化。本研究检测大鼠TEC（NRK-52E细胞）在含高浓度牛血清内蛋白（BSA）的培养基中是否发生转分化，以及shRNA-HIF—1α能否抑制BSA致NRK-52E细胞转分化的作用，以探讨HIF—1α在蛋白尿致肾脏纤维化中的作用。
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2011年第8期618-619,共2页
Chinese Journal of Nephrology
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