microRNA调控T细胞活化在多发性硬化发病中的作用

Role of microRNA-mediated T lymphocyte activation in multiple sclerosis: recent progress

多发性硬化(multiple sclerosis,MS)是一种能累及中枢神经系统的自身免疫性疾病。目前已知T细胞功能的异常是导致MS发病的主要原因。最近研究发现,microRNA在调控T细胞活化以及介导致病过程中起到关键作用,已成为当前研究的热点之一。本文就目前已知的microRNA在调控T细胞活化并介导MS发病机制的相关研究作一综述。

Multiple sclerosis（MS） is an autoimmune disease involving the central nervous system.T lymphocytes are known to play an important role in maintaining the body＇s autoimmunity,and their dysfunction is the leading cause of MS.Recent study has found that microRNAs play a key role in T lymphocyte activation and pathogenesis of neurodegenerative diseases,and it has become a focus of study.This article reviews the roles of existing microRNA in T lymphocyte activation and in the pathogenesis of MS.