多孔羟基磷灰石微球的药物缓释性能

Drug Release Behavior of Porous Hydroxyapatite Microspheres

用锂钙硼(LCB)玻璃在磷酸盐溶液中的原位转化反应制备多孔羟基磷灰石(HA)微球,表征微球的物相组成、孔结构和形貌,以溶菌酶为药物模型研究了药物的缓释性能。结果表明,所制备的HA微球具有较好的孔结构。当溶菌酶溶液的浓度较低时,HA微球将溶菌酶吸附在微球的外表面;当浓度较高时,更多的溶菌酶扩散进入HA微球的微孔中,使缓释效果明显改善。当溶菌酶溶液的初始浓度为1.0 mg/ml时,载药HA微球的释药周期可达800 h以上。

Porous hydroxyapatite（HA） microspheres were prepared by a situ Li-Ca-B glass conversion process.The phase composition,pore structure and morphology were characterized by XRD,SEM and BET.The results show that the resultant microspheres possess good internal porous structure.The release behavior of lysozyme as a model drug was investigated in the present work.The results show that lysozyme molecules mainly are absorbed on the external surface of the porous HA when concentration of lysozyme is low.A large amount of lysozyme is loaded in the pores of the microspheres when high concentration of lysozyme is used,which effectively prolonged the drug release.The loading behavior was successfully observed in the 1.0 mg/ml lysozyme solution and the drug can still be released after 800 hours.