肠出血性大肠杆菌O-104:H4型感染

Enterohemorrhagic escherichia coli(EHEC) O-104:H4 infection

出血性大肠杆菌(EHEC)O-104:H4能产生一种类志贺样毒素,此毒素可以直接导致肾脏和内皮细胞的损伤,而且可以黏附在肠上皮细胞导致血性腹泻,严重者可并发溶血性尿毒症。EHEC O-104:H4的传播途径主要通过被污染的食物、水源及接触传播。"芽苗菜"为本次德国暴发的急性肠道传染病疫情源头。当前最主要的任务是需要对EHEC O-104:H4感染设计和筛选出特效的抗生素并进行前瞻性研究。现已研制的EHEC O-157:H7 ghost口服疫苗,可为O-104:H4型大肠杆菌疫苗研制提供借鉴。

Enterohemorrhagic Eseheriehia coli （EHEC） O-104：H4 strain produces a Shiga-like toxin （verotoxin） that may directly cause renal and endothelial cell damage and may also adhere to intestinal epithelium resulting in bloody diarrhea or even hemolytic-uremic syndrome （HUS） in severe cases. The transmission route of EHEC O-104 ：H4 strain is mainly through contaminated food, water source and human contact. ＂Poisonous bean sprouts＂ have been the source to recent German outbreak of acute enteric infection. At present, an overriding mission is to design and screen specific antibiotics for EHEC O-104：H4 infection and to validate these antibiotics in prospective studies. The already-available oral vaccine against EHEC O-157：H7 ghost may provide clues to tuture development of EHEC O-104 ： H4 vaccines.