感染自身免疫与心肌炎

The role of infection and autoimmunity in myocarditis

心肌炎临床表现多样,可以从轻度呼吸困难或胸痛自发缓解到心源性休克和猝死。目前仍是难于诊断和治疗的一种挑战性疾病。病毒感染和自身免疫性炎症是其主要发病机制;细胞因子在病毒感染进展为自身免疫性心肌病中起到重要的桥梁作用,进一步了解心肌炎的病因学和发病过程有利于指导治疗。

Myocarditis presents with a spectrum of symptoms ranging from mild dyspnea, self-limited chest pain to cardiogenic shock and sudden death, and so far remains challenging in terms of diagnosis and treatment. Viral infection and autoimmune inflammation are major mechanisms that underlie the pathogenesis of myocarditis. Cytokines have a role in bridging progression of viral infection and autoimmune myocarditis. Further study on the etiology and pathogenesis of myocarditis would benefit the treatment of this condition.