FGF21在PCOS患者血清中的表达及意义

Expression and Significance of FGF21 in the Serum of Patients with Polycystic Ovarian Syndrome

目的:评价多囊卵巢综合征(PCOS)患者血清中成纤维细胞因子21(FGF21)的表达,初步探讨FGF21在PCOS发病中的作用。方法:研究对象分为PCOS组和正常对照组。PCOS组分为肥胖患者和非肥胖患者。分别用酶联免疫法(ELISA)测定血清FGF21水平;采取磁酶免法测定黄体生成素(LH)、睾酮(T);应用化学发光法检测空腹血糖(FBG)、空腹胰岛素(Ins)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平。结果:PCOS组FGF21表达明显高于对照组(P<0.01),并且与体重指数(BMI)、Ins(r=0.423,P<0.01;r=0.341,P<0.05)成正相关;在PCOS组中,肥胖患者血清中的FGF21水平高于非肥胖患者(P<0.05),与IR、LH(r=0.440,P=0.046;r=0.44,P=0.044)成正相关。结论:PCOS患者血清中FGF21水平明显高于对照组,在PCOS组中肥胖患者血清中FGF21水平明显高于非肥胖患者。FGF21有望成为PCOS治疗中的新突破。

Objective：To investigate the expression of serum fibroblast growth factor 21（FGF21）in patients with polycystic ovarian syndrome （PCOS） and to explore the influence of serum FGF21 in PCOS.Methods：The subjects were divided into two groups： PCOS group and control group, while PCOS group was divided into obesity patients and nonobesity patients. FGF21 level in serum were measured by Enzyme-linked immunosorbent assay（ELISA）, while luteinizing hormone（LH）,total testosterone（T）were measured by Magnetic enzyme immunoassay method and fasting blood glucose（FBG）、fasting insulin（Ins）、high-density lipoprotein（HDL）、low-density lipoprotein（LDL）were measured by Chemiluminescence.Results：Serum FGF21 levels in PCOS group were significantly higher than in controls（P0.01）and had a positive correlation with Body Mass Index（BMI）、Ins（r=0.423、P0.01;r=0.341、P0.05）. In PCOS group, serum FGF21 levels in obesity patients were significantly higher than in nonobesity patients（P0.05）and had a positive correlation with IR and LH（r=0.440 P=0.046;r=0.44 P=0.044）.Conclusions：The levels of serum FGF21 in PCOS group are significantly higher than control group;In PCOS group,the levels of serum FGF21 in obesity patients are significantly higher than nonobesity patients;and FGF21 is expected to be a new breakthrough in the therapy of PCOS.