初发2型糖尿病患者胰岛素抵抗与血小板参数的相关性研究

Relationship between Insulin Resistance and the Platelet Parameters in Newly Diagnosed Type 2 Diabetic Patients

目的探讨初发2型糖尿病(T2DM)患者胰岛素抵抗(IR)与血小板参数的相关性。方法检测90例住院或门诊的初发T2DM患者和90例健康体检者(对照组)的血压、血小板参数[包括血小板计数(PLT)、血小板平均体积(MPV)和血小板体积分布宽度(PDW)]、空腹血糖(FBG)、空腹胰岛素(FINS)、血脂[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]等指标。结果 (1)初发T2DM组患者FBG、TC、TG、MPV及PDW均显著高于对照组(P<0.05)。(2)T2DM患者中,IR组患者FBG、胰岛素抵抗指数(HOMA-IR)、TC、TG、MPV及PDW均显著高于非IR组(P<0.05);T2DM组患者中MPV与HO-MA-IR呈正相关(r=0.351,P=0.03);(3)IR组在IR改善后FBG、HOMA-IR、TG、MPV、PDW较治疗前均显著下降(P<0.05)。结论初发T2DM患者的血小板活性增强,改善IR可降低血小板活性,对防治糖尿病血管并发症有益。

Objective To investigate the relationship between insulin resistance and the platelet parameters in newly diagnosed type 2 diabetic patients. Methods Blood press, the platelet parameters [ including blood platelets count （ PLT）, mean platelet volume （MPV）, and platelet distribution width （PDW） ], fasting blood glucose （FBG）, fasting insulin, blood lipid [ triglyceride （ TG）, total cholesterol （ TC ）, high density lipoprotein cholesterol （ HDL - C ）, low density lipoprotein cholesterol （ LDL - C） ] were determined in 90 patients with newly diagnosed type 2 diabetes and 90 healthy controls. Results Levels of FBG, TG, TC, MPV, and PDW in the newly diagnosed type 2 diabetic patients were significantly higher than those in healthy controls （P 〈0. 05） . Among T2DM patients, levels of FBG, HOMA - IR, TG, TC, MPV, and PDW in the insulin resistance group were significantly higher than those in the non - insulin resistance group （P 〈 0. 05 ） ; MPV level was positively correlated with HOMA - IR （ r = O. 351, P = O. 03 ） . Levels of FBG, HOMA - IR, TG, MPV, and PDW significantly decreased in the insulin resistance group after treatment in comparison with before （ P 〈 O. 05） . Conclusion The activity of plate let is enhanced in newly diagnosed type 2 diabetic patients, which could be reduced by improvement of the insulin resistance status.