摘要
[目的]建立良好的肝癌动物模型,为人类治疗肝癌服务。[方法]简单介绍几种比较常见的肝癌动物模型。[结果]目前比较常用的动物模型有:Hepa1-6细胞诱发C57BL/6J小鼠原位肝癌模型、采用Hep_G2细胞株建立裸鼠肝癌模型、直接移植法建立大鼠肝癌模型、直接注入法建立大鼠肝癌模型、免疫重建荷人高转移肝癌SCD鼠模型、其他移植性肝癌模型和基因性肝癌模型。[结论]动物模型是进行试验研究的重要手段和平台,建立肝癌动物模型对肝癌发生机制、诊断与治疗研究有很重要的意义。
[Objective] To establish good animal models of liver cancer and serve treatment of liver cancer in humans.[Method] Several common animal models of liver cancer were introduced briefly.[Result] The commonly used animal models include C57BL/6J mouse model of orthotopic liver cancer induced with Hepa1-6 cells,nude mouse model of liver cancer established with Hep_G2 cell lines,rat liver cancer model established through direct transplantation or direct injection,HU-PBL-SCID mice model,and other transplanted liver cancer models or genetic liver cancer models.[Conclusion] Animal model is an important means and platform for experimental studies.To establish animal models of liver cancer is of important significance for studies on pathogenesis,diagnosis and treatment of liver cancer.
出处
《安徽农业科学》
CAS
北大核心
2011年第20期12264-12266,共3页
Journal of Anhui Agricultural Sciences
关键词
肝癌
动物模型
Liver cancer
Animal models
