盐酸氟桂利嗪预防月经期偏头痛的疗效观察

PROPHYLACTIC EFFECT OF FLUNARIZINE HYDROCHLORIDE ON PATIENTS WITH MENSTRUAL MIGRAINE

目的:探讨盐酸氟桂利嗪(flunarizine hydrochloride)预防月经期偏头痛的临床策略和疗效。方法:选择2008年1月至2009年1月在门诊就诊的月经期偏头痛患者154例,随机分为对照组、5mg组和10mg组。收集患者年龄、头痛时间、偏头痛家族史、头痛严重程度及头痛频率等资料。对照组予以健康宣教,无药物处理,10mg组在月经期前后给予盐酸氟桂利嗪10mg预防治疗(月经期前2天至后3天),5mg组给予5mg预防治疗。比较三组患者头痛程度、发作频率、不良反应和远期疗效。采用视觉模拟评分法(visual analogue scale,VAS)比较干预前后各组头痛程度的变化,分析药物剂量与预防效果的关系。结果:对照组和5mg组比较,两组在头痛程度、频率和复发率方面均无显著性差异(P>0.05);对照组和10mg组比较,两组在头痛程度、频率和复发率方面均有显著性差异(P<0.05);10mg组和5mg组比较,10mg组无痛率明显高于5mg组,两组比较有显著性差异(P<0.05)。10mg组发作频率和复发率明显低于5mg组(P<0.05)。两组的不良反应无显著性差异(P>0.05)。结论:月经期前2天至后3天每天给予盐酸氟桂利嗪10mg控制头痛程度和频率的效果较好,预防复发的远期疗效较好,不良反应无明显增加。

Objective： To observe the effect of flunarizine hydrochloride （sibelium） on menstrual migraine. Methods： Included were 154 out-patient menstrual migraineurs from January 2008 to January 2009. The subjects were randomly divided into control group（ n =46） , 10mg group （n = 54） and 5rag group （n = 54）. The change of the degree of headache, headache attack frequency, adverse effects and protective efficacy were compared after treatment, using visual analogue scale （VAS） as criteria. Re- sults： There were significant differences in the headache degree, headache attack frequency and relapse rate between the I0 mg group and control group（P 〉0.05）, but not in the 5mg group and control （P 〈 0.05 ）. The aponia ratio was higher in 10mg versus 5mg group （ P 〈0.05 ） , the attack frequency and relapse rate was lower in lOmg versus 5rag group （P 〈0.05 ）. There was no significant difference in the adverse effects between the two treatment groups （P 〉 0.05 ）. Conclusion ：Taking 10rag Sibelium orally 2 days before up to 3 days after the menstrual cycle could control the menstrual migraine by decreasing the degree, frequency and relapse rate of the headache arrack, without causing more adverse effects.