纳米混悬液的制备方法及其在药物输送中应用的研究进展

Advances in Study on the Preparation of Nanosuspensions and the Application of Drug Delivery

纳米混悬液系采用少量表面活性剂或其它载体等稳定纯药物粒子所形成的一种亚微米胶体分散体系。纳米混悬液可增大难溶性药物的溶解度,提高药物的有效性和安全性等。通过查阅国内外相关文献,文章就纳米混悬液的制备方法、评价方法及在药物输送中的应用进行了综述。纳米混悬液的制备技术主要有两种,即Bottom up技术和Top down技术。其评价方法主要包括:粒径及粒径分布、Zeta电势、药物晶体状态等。纳米混悬液在各种给药途径中均有优势。

Nanosuspensions consist of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Nanosuspensions not only solve the problems of poor solubility and bioavailability but also improve the efficacy and safety of drugs. The article includes the methods of its preparation, evaluation and application in drug delivery. By consulting relevant literature, the methods of preparation, methods of evaluation and applications in drug delivery are reviewed. The preparation of nanosuspension can be broadly classified into two categories： （i） top-down approache （ii） bottom-up approache. The methods of evaluation are inrolved with particle size and size distribution, Zeta potential, and drug crystal state. Nanosuspension has a lot of advantages in many routes of administration. Nanosuspension as a new drug carrier has broad prospects