摘要
目的:通过动物实验观察复方乳没利多卡因缓释贴膜的镇痛药效。方法:利用小鼠热板法实验以舔后足所需时间作为小鼠的痛阈值来验证疗效。结果:复方乳没利多卡因缓释贴膜剂大、中、小剂量在给药后10分钟、30分钟、1小时、3小时、4小时、14小时、24小时、32小时与给药前比较均有升高的趋势,其中1小时和3小时时镇痛作用较明显,在1小时大、中剂量组的痛阈与给药前比较差异具有显著性(P<0.05),其余时间段镇痛作用不明显(P>0.05)。结论:复方乳没利多卡因缓释贴膜有明显的止痛治疗作用,并且其中1～3小时时镇痛作用较明显,镇痛效果最好。
Objective：To study the effect of relieving pain about slow -release patch of compound recipe of frankincense and myrrh and lidocaine in mouse model. Methods：To check the effect through the time of the mouse licking metapedes in the hot plate experiment as the pain threshold. Result：The role of slow - release patch of compound recipe of frankincense and myrrh ang lido- caine in large dose, middle dose and small dose group was all increased at time lOmin, 30 min, 1 h, 3h, 14h, 24h, 32h, espelially at lh and 3h. At 1h, there was significant difference about the pain threshold of the large dose and middle dose group mouse compared to the no - olosage mouse （ P 〈 0.05）. The role of relieving pain was not significant at the rest time（ P 〉 0. 05 ）. Conclusion： The slow - release patch of compound recipe of frankincencse and myrrh and lidocaine has significant role in relieving pain, especially at time 1h,3h.
