六神丸合剂联合高氧液治疗晚期肿瘤患者压疮的效果评价

Clinical effect of Liushen mixture combined with hyperoxia solution to treat pressure sores of patients with advanced cancer

目的探讨六神丸合剂联合高氧液治疗晚期肿瘤患者压疮的临床效果。方法将晚期肿瘤压疮患者43例随机分为实验组21例和对照组22例。2组患者均给予常规清创治疗护理后，实验组采用六神丸30-60粒研成粉末，2％利多卡因3-8ml调和致完全溶解后均匀涂抹于创面，并以浸有高氧液的无菌纱布外敷，保鲜膜固定，定时更换；对照组采用磺胺嘧啶银外涂创面后无菌纱布覆盖，定时更换。分别观察2组压疮的治愈率、有效率和愈合时间。结果实验组压疮的治愈率和有效率分别为76．19％和90．48％，对照组治愈率和有效率分别为45．45％和63．64％，2组比较差异显著；实验组Ⅲ期压疮的治愈时间为（13．60±4．92）d，对照组的治愈时间为（20．76±5．51）d，实验组Ⅲ期压疮的治愈时间显著短于对照组。结论六神丸、利多卡因合剂联合高氧液治疗晚期肿瘤患者压疮疗效显著，值得临床推广应用。

Objective To study the clinical effect of Liushen mixture combined with hyperoxia solution to treat the pressure sores of advanced cancer patients. Methods 43 cases of advanced cancer patients with pressure sores were randomly divided into the experimental group （21 patients）and the control group （22 patients）. All patients received conventional care after debridement, the experimental group was treated by 30 to 60 Liushen pills grinded into powder reconciled with 3 -8 ml 2% lidocaine to cover the affected area as external fomentation by sterile gauze which was soaked by hyperoxia solution, fixed with cling film, regular replacement. The control group was coated with silver sulfadiazine sterile gauze and regular replacement. The cure rate, efficiency rate, and healing time of pressure sores of the two groups were observed respectively. Results In the experimental group the cure rate and efficiency rate were respectively 76.19% and 90.48%, and the cure rate and efficiency rate of the control group were 45.45% and 63.64%, the difference was statistically significant. In the experimental group the phase Ⅲ pressure sores＇ healing time was （13.60 ± 4.92）days, the healing time of the control group was（20.76 ± 5.51 ）days, the difference was statistically significant. Conclusions Liushen pills and lidocaine mixture combined with hyperoxia solution to treat the pressure sores of advanced cancer patients have significant effect and are worthy of clinical application.