1,2,4-噁二唑-苯氧烷基取代的异噁唑衍生物的合成及抗病毒活性

Synthesis and anti-virus activities of 1,2,4-oxadiazole-phenoxy alkyl-isoxazole derivatives

对普来可那利结构修饰,合成了6个1,2,4-噁二唑-苯氧烷基取代的异噁唑衍生物(10a～10f),结构均经IR、MS和1HNMR确证。测定所有目标化合物抗人鼻病毒N32的活性,初步药理活性实验结果表明,6个化合物抗人鼻病毒N32活性均强于阳性对照药物普来可那利,值得进一步研究。

The structure of pleconaril was modified,and six 1,2,4-oxadiazole-phenoxy alkyl-isoxazole derivatives were synthesized.The structures of all novel compounds were determined by IR,MS and 1H NMR.Inhibitory effect of these compounds on human rhinoviruses N32 in vitro was evaluated.The preliminary results showed that the inhibitory effect of the six compounds on human rhinoviruses N32 was stronger than that of pleconaril.Compounds 10a-10f are promising compounds worthy of further study.