新疆一枝蒿化学成分的研究

Chemical constituents from Artemisia rupestris L.

采用硅胶、Sephadex LH-20、C18等柱色谱方法对新疆一枝蒿Artemisia rupestris L.干燥地上部位的醇提物进行分离纯化,得到16个化合物(1～16)。通过1H NMR、13C NMR等波谱技术,16个化合物的结构分别鉴定为:一枝蒿酮酸(1),12-hydroxy-4,11(13)-guaiadien-3-one(2),木犀草素(3),5,7-二羟基-3',4'-二甲氧基黄酮(4),木犀草素7-O-β-D-葡萄糖苷(5),木犀草素7-O-[α-L-木糖-(1→6)-β-D-葡萄糖](6),蒙花苷(7),槲皮素(8),石吊兰素(9),栀子素丁(10),茵芋苷(11),豆甾醇-3-O-β-D-葡萄糖苷(12),1,2-O-异丙叉基-α-D-呋喃葡萄糖苷(13),天师酸(14),β-谷甾醇(15),胡萝卜苷(16)。其中化合物2,4,6,9,11～14均为首次从该植物中分离得到。

From the ethanol extract of the aerial parts of Artemisia rupestris,sixteen compounds were isolated by repeated column chromatography with silica gel,Sephadex LH-20 and C18.Their structures were identified by spectroscopic techniques（1H NMR,13C NMR and so on） as： rupestonic acid（1）,12-hydroxy-4,11（13）-guaiadi-en-3-one（2）,luteolin（3）,5,7-dihydroxy-3＇,4＇-dimethoxyflavone（4）,luteolin 7-O-β-D-glucoside（5）,luteolin 7-O-[β-D-xylopyranosyl-（1→6）-β-D-glucopyranoside]（6）,linarin（7）,quercetin（8）,nevadensin（9）,gardenin D（10）,skimmin（11）,stigmasterol-3-O-β-D-glucopyranoside（12）,1,2-isopropylidene-α-D-glucopyranose（13）,tianshic acid（14）,β-sitosterol（15） and daucosterol（16）.Among them,compounds 2,4,6,9,11-14 were isolated from this plant for the first time.