低分子肝素治疗重度子痫前期的临床观察

Clinical observation of low molecular heparin in the treatment of severe preeclampsia

目的:探讨低分子肝素治疗重度子痫前期的临床价值及治疗期间各项指标的变化。方法:将我院收集的156例患者随机分为治疗组和对照组,每组各78例,对照组应用常规治疗,包括解痉、镇静、降压,必要时给予扩容、利尿等治疗。治疗组在对照组治疗的基础上加用低分子肝素5 000 IU皮下注射,1次/d,5 d为1个疗程,观察两组患者各项指标的变化。结果:两组患者治疗后平均动脉压比较,治疗组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后24 h尿量比较,治疗组大于对照组,差异有统计学意义(P<0.05)。两组患者治疗后产后出血量比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上加用低分子肝素治疗重度子痫前期,可有效地降低血压、增加尿量、且不增加产后出血量,治疗安全、有效,值得临床推广应用。

Objective：To investigate the clinical efficacy of Low molecular heparin in the treatment of severe preeclampsia and various changes of the indicators during the treatment.Methods：156 cases of patients who were collected from our hospital were randomly divided into control group and treatment group,and there were 78 cases in each group.The control group was given conventional treatment including spasmolysis,calm,control blood pressure,and expansion,diuretic when necessary.The treatment group combined with Low molecular heparin 5 000 IU subcutaneous injection based on the control group,1 time/d,5 d for a course of treatment.The indicators′ various changes of the two groups were observed.Results：Mean arterial pressures of the two groups after treatment was compared.The mean arterial pressures of treatment group were lower than that of the control group,there was a significant difference between them（P0.05）.24 h urine of the two groups after treatment were compared.The 24 h urine of treatment group was more than that of the control group,and there was a significant difference between them（P0.05）.Postpartum hmorrhage of the two groups after treatment was com-pared,and there was no significant difference（P0.05）.Conclusion：Low molecular heparin combined with conventional treatment in severe preeclampsia can reduce the blood pressure,increase urine and have no inference of postpartum hemorrhage.It is safe,effective,and it is worthy of clinical application.