逍遥散联合草酸艾司西肽普兰片治疗抑郁症疗效观察

The efficacy observation of Xiaoyaosan combined with Escitalopram in the treatment of depression

目的:比较逍遥散加减联合草酸艾司西酞普兰片与单独使用草酸艾司西酞普兰片治疗抑郁症的疗效及安全性。方法:将确诊为抑郁症的60例患者随机分为治疗组(逍遥散加减联合草酸艾司西酞普兰片组)30例,对照组(草酸艾司西酞普兰片组)30例,用汉密尔顿抑郁量表(HAMD)在治疗前及治疗后2、4、6、8周评定疗效,用不良反应量表(TESS)评定安全性。结果:治疗组有效率为93.33%,对照组为83.33%,两组比较,差异有统计学意义(P<0.05);治疗后2、4、6、8周,治疗组HAMD评分均低于对照组,差异有统计学意义(P<0.05);治疗组出现不良反应4例,对照组出现12例,两组比较,差异有统计学意义(P<0.05)。结论:逍遥散加减联合草酸艾司西酞普兰片治疗抑郁症起效快,疗效好,不良反应少。

Objective：To compare curative effect and safety of Escitalopram combined with Xiaoyaosan with Escitalopram in the treatment of depression.Methods：60 cases of patients with depression were randomly divided into the treatment group（Xiaoyaosan subtract unfettered combined with Escitalopram group） and control group（Escitalopram group）,each 30 cases.Hamilton depression rating scale（HAMD） was used to evaluate the efficacy before the treatment and 2,4,6,8 weeks after the treatment,adverse reactions scale（TESS） was used to evaluate safety.Results：The effective rate of the treatment group was 93.33% and the control group was 83.33%,the difference was significant（P0.05）.2,4,6,8 weeks after the treatment,HAMD scores were lower in the treatment group than the control group,the difference was significant（P0.05）.The treatment group had 4 cases of adverse reactions,control group had 12 cases,the difference was significant（P0.05）.Conclusion：Xiaoyaosan subtract unfettered combined with Escitalopram in the treatment of depression shows good curative effect,and the adverse reaction is less.