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喷雾干燥法制备断血流皂苷微球 被引量:2

Prepared Clinopodii Saponin Microspheres by Spay Drying Method
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摘要 目的:探索喷雾干燥技术制备断血流皂苷微球的最佳工艺参数。方法:利用高效液相色谱法测定断血流皂苷A含量;以外观形态、载药量和包封率为指标,对进风温度、进样速度、增塑剂种类、药物与囊材比例等因素进行考察。结果:最佳工艺参数为进风温度90℃,进料速度2.5 mL.min-1,增塑剂为甘油,药物与囊材比例1∶4。结论:断血流皂苷微球质量符合预期要求;采用喷雾干燥法制备断血流皂苷微球工艺合理、可行。 Objective:To explore the optimun technique parameters on preparing clinopodii saponin microspheres by spray drying technique.Method:HPLC were used to determine the content of clinopodii saponinA,Investigate the influence factors with appearance,the loading capacity and entrapment efficiency as indexes,such as inlet temperature,feeding rate,kinds of plasticizer,ratio of drug to coating material.Result:The optimum technique parameters was as follows: inlet temperature at 90 ℃,feeding rate as 2.5 mL·min-1,kinds of plasticizer was glycerine,ratio of drug to coating material was 1∶4.Conclusion:Clinopodii saponin microspheres accorded with expected demand.The optimum technique was reasonable,feasible.
机构地区 赣南医学院
出处 《中国实验方剂学杂志》 CAS 北大核心 2011年第17期17-19,共3页 Chinese Journal of Experimental Traditional Medical Formulae
基金 江西省卫生厅中医药科研项目(2008A123)
关键词 断血流皂苷 微球 喷雾干燥 clinopodii saponin microsphere spray drying
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  • 1Huang Y C,Yeh M K,Chiang C H. Formulation factors in preparing BTM--chitosan microspheres by spray drying method [ J ]. Inter J Pharm, 2002,242 ( 1/2 ) : 239.
  • 2Desai K G,Park H J. Effect of manufacturing paramete on the characteristics of vitamin cencapsulated tripolyphos- phate-chitosan mierospheres prepared by spray-drying [ J ]. J Microencapsul,2006,23 ( 1 ) :91.
  • 3Corrigan D O, Healy A M, Corrigan O I. Preparati and release of salbutamol from chitosan and chitosan cospray dried compacts and multiparticulates [ J ]. E J Pharm Biopharm ,2006,62 ( 3 ) :295.

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