柴胡皂苷对肝脏的药理毒理作用研究进展

Research Development on Pharmacological Effects and Hepatotoxicity of Bupleurum Saikosaponin

介绍柴胡皂苷对肝脏功效与肝毒性的最新研究进展,为相关研究提供文献依据和研究思路。对柴胡皂苷近5～10年来国内外相关文献21篇进行整理、分析与归纳。研究认为柴胡皂苷是柴胡发挥疏肝解郁功效的主要物质基础;临床应用和现代研究过程中亦逐渐认识到柴胡皂苷具有肝脏毒性,其肝损伤机制与途径主要与多途径的氧化应激损伤有关。柴胡的毒性研究及毒性物质的安全控制需在其功效表达和功效物质分离与控制过程中进行,才能提出切合柴胡临床使用过程中不良反应的预警方案和早期诊疗措施,保证其临床用药安全,科学应对国内外有关柴胡毒性的相关问题。

Objective： By summarizing the latest research development on pharmacological effects and hepatotoxicity of Bupleurum saikosaponin,to provide the literature accordance and research ideas.Method： By searching the CNKI and NCBI databases,the related references in recent 5-10 years both at home and abroad about Bupleurum saikosaponin were collected,analyzed and summarized.Result： Bupleurum saikosaponin were the mainly chemical components of Bupleurum which had the hapatoprotective effect;the hepatotoxicity of Bupleurum saikosaponin were gradually recognized on the process of clinical application and modern research,and the hepatic damage mechanism and channel were mainly related with the multi-channel oxdative injury.Conclusion： Only in the process of effect expression and the effctive materials separation and control of Bupleurun when studying its toxicity and toxic materials,it could propose the early adverse reaction warning program and early diagonosis treatment measures properly and guarantee the clinical use of Bupleurum safely,so that to deal with relative problems of its hepatotoxicity both at home and abroad scientifically.