胃癌组织中EGFL7的表达及其临床病理特征的关系研究

Expression of EGFL7 in Gastric Carcinoma and Its Correlation with Tumor Clinical and Pathological Features

目的:探讨胃癌组织中表皮生长因子样结构域(EGFL7)的表达及其与胃癌临床病理特征的关系。方法:采用免疫组织化学SP法分别检测45例胃癌组织中EGFL7的表达水平及微血管密度(MVD,CD34标记),分析EGFL7的表达与MVD及胃癌临床病理特征之间的关系。结果:EGFL7的表达在有淋巴结转移组中的阳性率(84.6%)高于无淋巴结转移组(57.9%),在浸润浆膜层组中的阳性率(84.4%)高于未浸润浆膜层组(46 2%)。胃癌组织中EGFL7的表达与淋巴结转移和浸润程度呈正相关(P<0 05),但与患者的年龄、性别、肿瘤的分化程度无关(P>0.05)。胃腺癌低分化组MVD(37.62±10.42)高于高分化组(27.91±9.93)和中分化组(28.40±9.18);浸润至浆膜层组MVD(34.25±10.43)高于未至浆膜层组(26.69±8.66);有淋巴结转移组MVD(33.00±9.99)高于无淋巴结转移组(25.94 ±9.34)。癌组织中MVD值与分化程度、浸润深度及有无淋巴结转移呈正相关(P<0.05),但与年龄、性别无关(P>0.05)在EGFL7表达阳性的肿瘤组织中MVD均值为33.80±10.56,高于EGFL7表达阴性的肿瘤组织中MVD均值26.00 ±7.21(P<0.05),采用Pearson积差相关系数进行分析,发现MVD值与EGFL7的表达成正相关(r=0.313,P<0.05)。结论:EGFL7的高表达可能促进了胃癌的浸润和转移,其机制可能与促进胃癌组织中的血管新生有关。

Objective：To explore the expression of EGFLTin gastric carcinoma and its correlation with tmnor clinical and pathological features. Methods：The expression of EGFL7 protein and MVD in 45 cases gastric carcinoma was detected by immunohistochemieal methods. Result：The expression of EGFLTin the team which has lymph node metastasis（ 84.6% ）is higher than the team which hasn＇t （57.9%） , in the serosal invasion team（ 84.4% ） is higher than the team which doesn＇t have serosal invasion（46.2% ）. The expression of EGFL7 in gastric carcinoma is related with tumor invasion and lymph node metastasis （p 〈 0. 05 ）, but isn＇t related with the patients＇ age, sex and tumor differentiation （ p 〉 0.05 ）. The MVD of poorly differentiation team （ 37.62 ± 10.42 ） is higher than the well - differentiation team （27.91 ± 9.93 ） and differentiated team （28.4±9. 18 ）. The serosal invasion team＇ s MVD （ 34.25 ±10.43 ） is higher than the team which is not （ 26. 69 ±8：66 ）, the team＇s MVD which has lymph node metastasis （33.00 ± 9.99 ）is higher than the team which hasn＇t （25.94 ±9. 34）. The MVD is related with tumor differentiation, invasion and lymph node metastasis, but isn＇t related with the age and sex （ p 〉 0. 05 ）. MVD in the tumor which express EGFL7 is 33.80 ±10. 56,that is higher than the MVD in the tumor which don＇t express EGFL7（26.00 ±7. 21 ） （p 〈0.05）. Pearson analysis shows MVD and EGFL7 expression is positive correlation （ r = 0. 313, p 〈 0, 05 ）. Conclusion ： High expression of EGFL7 would progress the inf/itration and metastasis of gastric caicinoma. The mechanism maybe related with angiogenesis.