氯沙坦对糖尿病肾病患者氧化应激的影响研究

目的观察氯沙坦对糖尿病肾病患者氧化应激的影响。方法选择收治的43例糖尿病肾病患者为观察组,在基础治疗的同时采用氯沙坦治疗,比较治疗前后患者的血、尿氧化应激指标的变化,并选择同期健康体检的40例作为对照组。结果糖尿病肾病患者的血SOD活性降低,MDA、ox-LDL和AOPPs均升高,与对照组比较,差异均有统计学意义(P<0.05);尿SOD活性降低,MDA、MCP-1、UAER均升高,与对照组比较,差异均有统计学意义(P<0.05);氯沙坦治疗后,观察组的血、尿氧化应激指标均得到明显改善,与治疗前比较,差异有统计学意义(P<0.05)。结论氯沙坦对糖尿病肾病患者氧化应激有一定的抑制作用,对患者的肾脏具有保护作用,值得临床关注。

Objective To investigate the influence of Losartan on oxidative stress of diabetic nephropathy patients. Methods From December 2009 to July 2010 in our hospital, 43 diabetic nephropathy patients as the observation group, they were treated with Losartan on the basis of initial therapy, and 40 healthy cases over the same period as the control group, then compared the changes of oxidative stress parameters of two groups. Results In diabetic nephropathy patients, the blood SOD activity decreased, but MDA, ox2LDL and AOPPs were increased, compared with the control group, the differences were statistically significant （P〈0.05）; the urinary SOD activity decreased, MDA, MCP-1, UAER were increased, compared with the control group, the differences were statistically significant （P〈0.05）; after Losartan treatment, the indicators of oxidative stress in serum and urine were significantly improved, compared with before treatment, the differences were statistically significant （P〈0.05）. Conclusion Mitiglinide and Nateglinide have a certain inhibitory effect on oxidative stress of diabetic nephropathy patients, and has protective effect on kidney of patients, it is worth popularizing. [Key words]