C反应蛋白浓度与多囊卵巢综合征胰岛素抵抗相关性分析

目的探讨C反应蛋白(CRP)的水平的变化与多囊卵巢综合征(PCOS)患者的胰岛素抵抗的相关性。方法选取40例PCOS患者按体重指数(BMI)分为正常体质量PCOS组(19例)和肥胖PCOS组(21例),44例正常妇女分为正常体质量对照组(20例)和肥胖对照组(24例)。收集相关临床资料,测定相关指标。结果 PCOS患者LH、FSH、T、FPG、FINS、CRP浓度均显著高于对照组,ISI显著低于对照组。经相关分析,血清CRP水平与BMI呈正相关,与ISI呈负相关。结论 PCOS患者体内存在慢性亚临床炎症反应;其水平与PCOS患者胰岛素抵抗程度密切相关。

Objective To investigate the relationship between C-reactive protein （CRP） level and insulin resistance in women with polycystic ovary syndrome（PCOS）.Methods 40 patients with PCOS（non-obese PCOS group,19 cases;obese PCOS group,21 cases） and 44 healthy women（non-obese control group,20cases;obese control group,24cases） were selected.relevant indicators were measured.Results LH、FSH、T、FPG、FINS and CRP in patients were significant higher than those in controls;Insulin sensitive index（ISI） in PCOS was significantly lower compared with controls.CRP showed positive association with BMI,and negative association with ISI.Conclusion There was low grade chronic inflammation in patients with PCOS.In patients with PCOS,and the level of CRP could reflect the degree of insulin resistance.